Physical activity counteracted associations of exposure to mixture of air pollutants with mitochondrial DNA copy number among rural Chinese adults

Exposure to single air pollutant and physical activity (PA) were associated with an altered mitochondrial DNA copy number (mtDNA-CN). However, studies on the interactive effects of or a mixture pollutants PA mtDNA-CN limited. A total 2707 Chinese adults obtained from Henan Rural Cohort Study. Spatiotemporal models used estimate particulate matter (PMs) (PM aerodynamic diameter ? 1.0 ?m (PM1), ?2.5 (PM2.5) 10 (PM10)) nitrogen dioxide (NO2) concentrations. Relative was measured by quantitative real-time polymerase chain reaction. Linear regression quantile g-computation applied examine associations relative mtDNA-CN. The visualized using Interaction plots. Each 1 ?g/m3 increment in PM1, PM2.5, PM10 NO2 5.11% (95% confidence interval: 3.71%, 6.53%), 6.77% (4.81%, 8.76%), 3.05% (2.22%, 3.87%) 4.99% (3.45%, 6.55%) increase one-quartile four related 0.053 (0.032, 0.075) Negative interaction observed. positive counteracted at certain levels, implying that may be costless effective approach decrease negative pollution